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Phenotypes Associated with This Genotype
Genotype
MGI:5613158
Allelic
Composition
Dmrta2tm1Ejbd/Dmrta2tm1Ejbd
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmrta2tm1Ejbd mutation (0 available); any Dmrta2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die within hours after birth

nervous system
N
• normal apoptosis in the dorsal telencephalon
• at E11.5, the number of apical mitotic progenitors is slightly increased with a larger increase in basal mitotic progenitors compared with wild-type cortices
• at E18.5, both apical and basal progenitors are decreased compared to in wild-type cortices
• early forebrain defects at E10.5 and E15.5 with absence of invaginations of the medial wall, smaller anlages and absent midline structures
• severely impaired differentiation
• disorganized with bulges protruding to the pial surface in some cases
• less well formed than in wild-type mice
• however, the proportional seize of the ventricular zone, subventricular zone and cortical plate are normal
• anlagen of the cerebral hemispheres is smaller than normal at E10.5
• reduced surface area at E18.5
• poor development of efferent fibers
• poorly differentiated structure and absent caudomedial portion
• defects in mediolateral patterning
• abnormal limit of the neocortex with the olfactory bulb
• reduced caudal neocortical regions
• thick cortical wall at E11.5
• however, size is normal at E14.5
• thin cortical walls at E18.5
• however, size is normal at E14.5
• reduced surface area at E18.5
• severe defects in thalamocortical axon and cortifugal axon
• impairment of axonal tracts crossing the midline
• loss of the connections between the cortex and the thalamus

growth/size/body
• in mice that survive at P4 and P90
• in mice that survive at P4 and P90

behavior/neurological
• possibly because of an inability to eat

cellular
• at E11.5, the number of apical mitotic progenitors is slightly increased with a larger increase in basal mitotic progenitors compared with wild-type cortices
• at E18.5, both apical and basal progenitors are decreased compared to in wild-type cortices


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory