Phenotypes Associated with This Genotype

Genotype
MGI:5613023

• Allelic Composition: Sox2^tm1.1Knd/Sox2^tm1.1Knd; Tbx6^tm1Pa/Tbx6^tm1Pa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal neural tube morphology ( J:217059 )

• absence of genes associated with neural tube development in the paraxial compartment concomitant with absence of tubular structures at E9.5

• expression analysis indicates absence of markers for the paraxial mesoderm, intermediate mesoderm and endoderm

• however, unlike mice homozygous for the Tbx6 mutation alone, no ectopic expression of Sox2 is seen in the neural tube

nervous system

abnormal neural tube morphology ( J:217059 )

• absence of genes associated with neural tube development in the paraxial compartment concomitant with absence of tubular structures at E9.5

• expression analysis indicates absence of markers for the paraxial mesoderm, intermediate mesoderm and endoderm

• however, unlike mice homozygous for the Tbx6 mutation alone, no ectopic expression of Sox2 is seen in the neural tube