Phenotypes Associated with This Genotype

Genotype
MGI:5604918

• Allelic Composition: Cyp26b1^tm1Dcp/Cyp26b1^tm1Dcp
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo development ( J:215225 )

• embryos exhibit anomalies in facial development

abnormal embryonic tissue morphology ( J:215225 )

• embryos exhibit anomalies in limbs and eyes

mortality/aging

perinatal lethality, complete penetrance ( J:215225 )

• pups die at birth

reproductive system

abnormal male meiosis ( J:215225 )

♂ • embryonic testicular germ cells exhibit continued DNA replication at E16.5 in contrast to wild-type, which arrest in G0/G1 at E16.5

♂ • germ cells from fetal testes cultured with retinoic acid exhibit an increased number of double stranded breaks at E15.5 as compared to wild-type