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Phenotypes Associated with This Genotype
Genotype
MGI:5604880
Allelic
Composition
Tg(MMTV-Erbb2)10Pjo/0
Genetic
Background
involves: BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 5% of females develop a salivary gland tumor
• 44% of females, but no males, develop mammary tumors after 5-10 months of age
• tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma
• 100% of males exhibit seminal vesicle and epididymis enlargement; the seminal vesicles are either enlarged or of a reddish color and indurated and show focal papillary hyperplasia and hypertrophy of the epithelium
• 5% of females and 8% of males exhibit unilateral proptosis; proptosis is due to a harderian gland tumor with severe bilateral hyperplasia and dysplasia of the epithelium

hematopoietic system
• 100% of females, but not males, exhibit splenomegaly
• red pulp is hypercellular and composed of immature elements of several lineages

immune system
• 100% of females, but not males, exhibit splenomegaly
• red pulp is hypercellular and composed of immature elements of several lineages

reproductive system
• 100% of males exhibit seminal vesicle and epididymis enlargement; the seminal vesicles are either enlarged or of a reddish color and indurated and show focal papillary hyperplasia and hypertrophy of the epithelium
• 100% of males exhibit seminal vesicle and epididymis enlargement; the lumen of the epididymis is often extremely dilated and focal areas of papillary epithelial hyperplasia are seen
• males are fertile in the first 2 months of age, but most become sterile by 3-4 months

neoplasm
• 5% of females develop a salivary gland tumor
• 44% of females, but no males, develop mammary tumors after 5-10 months of age
• tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma
• 5% of females and 8% of males exhibit unilateral proptosis; proptosis is due to a harderian gland tumor with severe bilateral hyperplasia and dysplasia of the epithelium

vision/eye
• 5% of females and 8% of males exhibit unilateral proptosis; proptosis is due to a harderian gland tumor with severe bilateral hyperplasia and dysplasia of the epithelium

integument
• 44% of females, but no males, develop mammary tumors after 5-10 months of age
• tumors are poorly differentiated typical adenocarcinomas, classified as Dunns type B adenocarcinoma

growth/size/body
• 100% of females, but not males, exhibit splenomegaly

digestive/alimentary system
• 5% of females develop a salivary gland tumor

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:72129


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory