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Phenotypes Associated with This Genotype
Genotype
MGI:5582593
Allelic
Composition
Ryr2tm3.1Amks/Ryr2+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm3.1Amks mutation (0 available); any Ryr2 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• leaky calcium channels in the sarcoplasmic reticulum of atrial myocytes
• induced by atrial burst pacing in 9 of 15 mice
• however, a 1,4-benzothiazepine (Rycal S107) prevents atrial burst pacing-induced atrial fibrillation

muscle
• leaky calcium channels in the sarcoplasmic reticulum of atrial myocytes
• leaky calcium channels in the sarcoplasmic reticulum of atrial myocytes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
catecholaminergic polymorphic ventricular tachycardia 1 DOID:0060675 OMIM:604772
J:212640


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory