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Phenotypes Associated with This Genotype
Genotype
MGI:5582588
Allelic
Composition
Tg(H2-K-IL6)2Srj/0
Genetic
Background
B6.Cg-Tg(H2-K-IL6)2Srj
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 15 week old mice exhibit enlarged spleen

hematopoietic system
• 15 week old mice exhibit enlarged spleen
• 28% of mice exhibit multicentric Castleman disease-like changes
• 32% of mice exhibit increased extramedullary hematopoiesis
• elevation in numbers of megakaryocytes in the spleen of 15 week old mice
• increase in granulocytopoiesis in the spleen in 15 week old mice
• 44% of mice exhibit plasmacytosis in the red pulp of the spleen
• massive accumulations of plasma cells in peripheral lymph nodes
• red pulp of spleen shows increased proliferation
• hyperplastic germinal centers in 15 week old mice
• 4-fold elevation in serum levels of IgG

immune system
• 15 week old mice exhibit enlarged spleen
• increase in granulocytopoiesis in the spleen in 15 week old mice
• 44% of mice exhibit plasmacytosis in the red pulp of the spleen
• massive accumulations of plasma cells in peripheral lymph nodes
• red pulp of spleen shows increased proliferation
• hyperplastic germinal centers in 15 week old mice
• 4-fold elevation in serum levels of IgG
• enlarged B-cell follicles in peripheral and deep abdominal lymph nodes that contain hyperplastic germinal centers and vascular proliferation and massive accumulations of plasma cells
• hyperplastic germinal centers in 15 week old mice
• 15 week old mice exhibit enlarged lymph nodes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
viral infectious disease DOID:934 J:185153


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory