About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5581451
Allelic
Composition
Alg10bnse5/Alg10bnse5
Genetic
Background
129S6.B6-Alg10bnse5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alg10bnse5 mutation (1 available); any Alg10b mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Outer hair cells of the cochlea are abnormal in Alg10bnse5/Alg10bnse5 mice

hearing/vestibular/ear
N
• endocochlear potential is normal
• severely; some with punctate pattern of prestin staining in cytosol
• however, degeneration is rescued by transgene expression of the gene
• however, ABR threshold is partially rescued by transgene expression of the gene
• however, ABR threshold is partially rescued by transgene expression of the gene
• however, deafness is rescued by transgene expression of the gene

nervous system
• severely; some with punctate pattern of prestin staining in cytosol
• however, degeneration is rescued by transgene expression of the gene

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
nonsyndromic deafness DOID:0050563 J:209766


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/06/2019
MGI 6.14
The Jackson Laboratory