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Phenotypes Associated with This Genotype
Genotype
MGI:5578736
Allelic
Composition
Crhm1H/Crh+
Genetic
Background
involves: C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhm1H mutation (2 available); any Crh mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice exhibit normal plasma ACTH, adiponectin and phosphate levels
• overt diabetes mellitus in most mice
• in female, but not male, mice
• in female, but not male, mice
• in fasted mice at 8, 12 and 16 weeks
• at 12 weeks in female and male mice
• in female and male mice at 8 to 12 weeks
• in 24 week old mice after a 4-hour fast
• in 24 week old mice after a 4-hour fast
• in female and male mice at 8 to 12 weeks
• in male, but not female, mice
• in female, but not male, mice
• by 19 weeks with frustosamine concentrations
• in fasted female and male mice at 8 weeks
• persisting at 12 and 16 weeks
• likely insulin resistance due to increased adiposity
• diminution of corticosterone circadian rhythm
• in female and male mice
• peak concentration is 8-fold greater than the nadir value
• in female, but not male, mice

skeleton
• increased adipocytes in the bone marrow
• with reduced percentage of corticoendosteal bone covered by osteoblasts
• reduced mineralization surface area
• reduced mineral apposition rates
• reduced bone formation rates

growth/size/body
• from 5 weeks in female and male mice
• in male mice only at 5 weeks
• in female mice from 6 weeks on

renal/urinary system
• in female and male mice
• peak concentration is 8-fold greater than the nadir value
• in female, but not male, mice
• in female and male mice

behavior/neurological
• in male, but not female, mice

liver/biliary system
• moderate diffuse microvesicular vacuolation

adipose tissue
• from 5 weeks in female and male mice
• increased adipocytes in the bone marrow

endocrine/exocrine glands
• increased weight

integument

limbs/digits/tail

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
primary hyperaldosteronism DOID:446 OMIM:605635
OMIM:613677
J:208708


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory