Phenotypes Associated with This Genotype

Genotype
MGI:5578560

• Allelic Composition: Tg(TG-TPR/NTRK1)5215Rstn/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:67120 )

• increase in follicular cellularity with irregular or colloid-deficient follicles

thyroid gland hyperplasia ( J:67120 )

• increase in follicular cellularity with irregular or colloid-deficient follicles

• hyperplasia is evident at 3 months of age, but onset can be seen as late as 10 months of age

increased thyroid carcinoma incidence ( J:67120 )

• hyperplastic thyroids show cellular invaginations into the follicle resembling micro-papillary structures of differentiated thyroid carcinoma

• 23% of mice younger than 7 months of age show thyroid carcinoma while 78% of mice older than 7 months of age develop thyroid carcinoma

• thyroid carcinoma is characterized by the proliferation of follicular epithelial cells containing scant cytoplasm, absent mitotic figures and papillae containing fibrovascular stalks, characteristic of differentiated carcinoma

• tumor metastases to local cervical lymph nodes, peripheral lymph nodes, or lungs are not seen as neither is inflammation

neoplasm

increased thyroid carcinoma incidence ( J:67120 )

• hyperplastic thyroids show cellular invaginations into the follicle resembling micro-papillary structures of differentiated thyroid carcinoma

• 23% of mice younger than 7 months of age show thyroid carcinoma while 78% of mice older than 7 months of age develop thyroid carcinoma

• thyroid carcinoma is characterized by the proliferation of follicular epithelial cells containing scant cytoplasm, absent mitotic figures and papillae containing fibrovascular stalks, characteristic of differentiated carcinoma

• tumor metastases to local cervical lymph nodes, peripheral lymph nodes, or lungs are not seen as neither is inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid gland papillary carcinoma		DOID:3969	OMIM:188550	J:67120