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Phenotypes Associated with This Genotype
Genotype
MGI:5578522
Allelic
Composition
Tg(TG-NRAS*Q61K)#Msnt/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 11% of mice develop follicular adenoma with a mixed papillary and follicular architecture by 18 months of age
• 29.5% of mice develop follicular carcinoma by 18 months of age, showing well-differentiated follicular or mixed papillary-follicular malignant component invading the stroma
• 10% of mice (25% of mice that have carcinoma) develop invasive poorly-differentiated carcinoma by 18 months of age
• however, squamoid, spindle and giant cell patterns of growth typical of undifferentiated carcinomas are not seen
• metastasis is seen within the parenchyma of the liver, the lung, or in the femur in some mice with poorly-differentiated carcinoma

endocrine/exocrine glands
• follicular cell hyperplasia is characterized by large, indistinct areas of small follicles with scant colloid and tall epithelial cells
• 11% of mice develop follicular adenoma with a mixed papillary and follicular architecture by 18 months of age
• 29.5% of mice develop follicular carcinoma by 18 months of age, showing well-differentiated follicular or mixed papillary-follicular malignant component invading the stroma
• 10% of mice (25% of mice that have carcinoma) develop invasive poorly-differentiated carcinoma by 18 months of age
• however, squamoid, spindle and giant cell patterns of growth typical of undifferentiated carcinomas are not seen

homeostasis/metabolism
• 60% of mice show on average a 2.5-fold higher levels of thyroid-stimulating hormone (TSH) at 4-8 months of age
• at 10-16 months of age, 40% of mice show TSH levels 1.5-fold higher than in controls
• however, T4 levels are normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
thyroid gland follicular carcinoma DOID:3962 OMIM:188470
J:210016


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory