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Phenotypes Associated with This Genotype
Genotype
MGI:5576781
Allelic
Composition
Arhgef2Gt(IST13976A8)Tigm/Arhgef2Gt(IST13976A8)Tigm
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef2Gt(IST13976A8)Tigm mutation (0 available); any Arhgef2 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mice exhibit perturbed migration of precerebellar neurons as indicated by the absence of the pontine gray nuclei and reticulotegmental nuclei which are formed through the anterior extramural migratory stream (AES) and enlarged external cuneate nuclei and smaller lateral nuclei due to disturbed posterior extramural migratory stream (PES)

immune system
N
• mice exhibit normal numbers of T cells, B cells and mononuclear phagocytes in spleen and lymph nodes
• macrophages exhibit an impaired ability to retrain the replication of vesicular stomatitis virus compared with wild-type cells
• in macrophages after transfection with high and low molecular weight pIpC
• in macrophages after infection with encephalomyocarditis virus (EMCV) or nonstructural protein 1 (NS1)-deficient influenza A variant
• however, secretion in response to TRIF, Myd88 or vesicular stomatitis virus infection is normal
• mice infected with influenza A exhibit more severe inflammation with increased epithelial damage, mononuclear cell infiltration and alveolitis compared with wild-type mice

growth/size/body
• mild microcephaly

hematopoietic system
• macrophages exhibit an impaired ability to retrain the replication of vesicular stomatitis virus compared with wild-type cells

nervous system
• mice exhibit perturbed migration of precerebellar neurons as indicated by the absence of the pontine gray nuclei and reticulotegmental nuclei which are formed through the anterior extramural migratory stream (AES) and enlarged external cuneate nuclei and smaller lateral nuclei due to disturbed posterior extramural migratory stream (PES)
• reduction in the volume of total brain size in adults indicating microencephaly
• reduction in the volume of the brainstem
• reduction in the volume of the cerebellum
• however, no major alterations in the distribution of neurons in the cortical layers, in the development of midbrain structures, and no abnormalities in the neocortex, and size of Purkinje cells and thickness of the cerebellar molecular layer are normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory