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Phenotypes Associated with This Genotype
Genotype
MGI:5575509
Allelic
Composition
Tg(Prnp-SNAP25/HTT*150Q)8Xjl/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Appearance of old Tg(Prnp-SNAP25/HTT*150Q)8Xjl/0 (150Q) mouse and control littermate at 13 months of age

mortality/aging
• mice die between 4 and 15 months of age

growth/size/body
• weight loss is seen after around 9 months of age

behavior/neurological
• in the light-dark box test, mice show a reduction in the time they stay in the light box with a decrease in cross time, suggesting increased anxiety
• mice show decreased acoustic startle responses
• mice show motor function deficits on the rotarod when they reach 11 months of age
• in the beam-walking assay, mice show a higher number of slips on the beam than controls, although the time to traverse the beam is no different

nervous system
• increase in astrocytic gliosis in the cortex, striatum, and cerebellum
• long-term potentiation (LTP) of field excitatory postsynaptic potentials (fEPSPs) is lower in the sensorimotor cortex
• glutamate release is selectively reduced in the striatum
• the amplitude of paired-pulse facilitation (PPF) induced by <100 ms intervals is lower than in wild-type mice

skeleton
• hunchback appearance

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:201806


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory