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Phenotypes Associated with This Genotype
Genotype
MGI:5574061
Allelic
Composition
Tg(Stat3*)9199Alau/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Stat3*)9199Alau mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Th17 differentiation is impaired as expression of IL-17 in na[?]ve CD4+ T cells is impaired when stimulated in the presence of TGF-beta and IL-6 and mice have fewer IL-17-positive CD4+ T cells in the lamina propria
• CD4+ T-cell production of IL-17A and IL-17F in cells from Citrobacter infected mice is reduced
• mice show increased numbers of neutrophils in the spleen following Citrobacter infection
• serum IgE levels are 6-fold higher
• mice immunized with a soluble antigen isolated from SEA to induce a Th2-driven immune response, exhibit enhanced IgE production compared to wild-type mice
• serum IgG1 is reduced
• mice immunized with a soluble antigen isolated from SEA to induce a Th2-driven immune response, exhibit reduced IgG1 production compared to wild-type mice
• serum IgG3 levels are reduced, but to a smaller extent than IgG1
• expression of IL-17 in naive CD4+ T cells is impaired when stimulated in the presence of TGF-beta and IL-6
• mice have fewer IL-17-positive CD4+ T cells in the lamina propria, but normal numbers of IFN-gamma-positive Th cells
• numbers of IFN-gamma expressing CD4+ T cells is increased in the colonic lamina propria compared to wild-type after Citrobacter infection
• CD4+ T-cell production of IL-17A, IL-17F, and IL-22 in cells from Citrobacter infected mice is reduced
• mice exhibit an increased inflammatory response after Citrobacter infection
• large bowels develop more inflammation than wild-type bowels after 9 days of Citrobacter infection
• mice show increased susceptibility to LPS-induced shock, with decreased survival, elevation in serum IL-12 and TNF-alpha levels, and a decrease in serum IL-10 levels
• mice exhibit increased susceptibility to intestinal Citrobacter rodentium infection, showing higher numbers of bacteria in the distal colons two weeks after infection, bacteria in spleens and livers, and increased numbers of neutrophils in the spleen
• mice begin to die at 11 to 14 days after intestinal Citrobacter rodentium infection unlike wild-type mice which are resistant to infection

mortality/aging
• mice begin to die at 11 to 14 days after intestinal Citrobacter rodentium infection unlike wild-type mice which are resistant to infection

digestive/alimentary system
• large bowels develop more inflammation than wild-type bowels after 9 days of Citrobacter infection

hematopoietic system
• Th17 differentiation is impaired as expression of IL-17 in na[?]ve CD4+ T cells is impaired when stimulated in the presence of TGF-beta and IL-6 and mice have fewer IL-17-positive CD4+ T cells in the lamina propria
• CD4+ T-cell production of IL-17A and IL-17F in cells from Citrobacter infected mice is reduced
• mice show increased numbers of neutrophils in the spleen following Citrobacter infection
• serum IgE levels are 6-fold higher
• mice immunized with a soluble antigen isolated from SEA to induce a Th2-driven immune response, exhibit enhanced IgE production compared to wild-type mice
• serum IgG1 is reduced
• mice immunized with a soluble antigen isolated from SEA to induce a Th2-driven immune response, exhibit reduced IgG1 production compared to wild-type mice
• serum IgG3 levels are reduced, but to a smaller extent than IgG1
• expression of IL-17 in naive CD4+ T cells is impaired when stimulated in the presence of TGF-beta and IL-6
• mice have fewer IL-17-positive CD4+ T cells in the lamina propria, but normal numbers of IFN-gamma-positive Th cells
• numbers of IFN-gamma expressing CD4+ T cells is increased in the colonic lamina propria compared to wild-type after Citrobacter infection
• CD4+ T-cell production of IL-17A, IL-17F, and IL-22 in cells from Citrobacter infected mice is reduced

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hyper IgE recurrent infection syndrome 1 DOID:3261 OMIM:147060
J:210877


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory