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Phenotypes Associated with This Genotype
Genotype
MGI:5571374
Allelic
Composition
Tg(Igh-ROR1)1Kip/0
Tg(Igh-V186.2-TCL1A)3Cro/0
Genetic
Background
B6.Cg-Tg(Igh-ROR1)1Kip Tg(Igh-V186.2-TCL1A)3Cro
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

neoplasm
• develop leukemia at a younger median age than mice with either transgene alone
• expansion of CD5+B220low B cells is accelerated and mice show earlier development of leukemia compared to single Tg(Igh-ROR1)1Kip mice

mortality/aging
• median survival is 50.6 weeks

hematopoietic system
• develop CD5+B220low B-cell lymphocytosis at a younger median age than mice with either transgene alone
• double mutants show an increase in percentage of CD5+B220low B cells among blood lymphocytes compared to single Tg(Igh-V186.2-TCL1A)3Cro mice

immune system
• develop CD5+B220low B-cell lymphocytosis at a younger median age than mice with either transgene alone
• double mutants show an increase in percentage of CD5+B220low B cells among blood lymphocytes compared to single Tg(Igh-V186.2-TCL1A)3Cro mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory