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Phenotypes Associated with This Genotype
Genotype
MGI:5570747
Allelic
Composition
Tg(Slc1a2-tTA)#Waw/0
Tg(tetO-MYCN,-luc)#Waw/0
Genetic
Background
involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice develop cerebellar tumors that show histology of classic medulloblastoma and large cell anaplastic medulloblastoma
• classic tumors consist of cells with moderate stromal content, low to intermediate vascularity, and variable anaplasia
• large cell anaplastic tumors have larger cells which show high nuclear-to-cytoplasmic ratios, polygonal cell morphology, and high levels or anaplasia and invasion which disrupts the molecular layer, Purkinje layer, and internal granular layer
• mice placed on doxycycline (dox) at P1 for 30 days do not develop tumors at P200
• acute treatment with dox results in a decrease in apoptotic cells and in cell proliferation in tumors

mortality/aging
• survival is 80% at 100 days of age and 60% at 200 days of age
• adult mice with tumors placed on dox survive through 200 days

neoplasm
• a few mutants show disseminated tumor in the lumbrosacral region, partially encasing nerve roots in the subarachnoid spaces adjacent to the spinal cord, indicating spinal metastases
• spinal metastases are discontinuous with primary tumors, suggesting leptomeningeal spread through cerebrospinal fluid
• mice develop cerebellar tumors that show histology of classic medulloblastoma and large cell anaplastic medulloblastoma
• classic tumors consist of cells with moderate stromal content, low to intermediate vascularity, and variable anaplasia
• large cell anaplastic tumors have larger cells which show high nuclear-to-cytoplasmic ratios, polygonal cell morphology, and high levels or anaplasia and invasion which disrupts the molecular layer, Purkinje layer, and internal granular layer
• mice placed on doxycycline (dox) at P1 for 30 days do not develop tumors at P200
• acute treatment with dox results in a decrease in apoptotic cells and in cell proliferation in tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:160518


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory