Phenotypes Associated with This Genotype

Genotype
MGI:5568558

• Allelic Composition: Serpina12^tm1Jwada/Serpina12^tm1Jwada
• Genetic Background: B6JJcl.129P2-Serpina12^tm1Jwada

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208508 )

N • mice fed a high fat, high sucrose diet exhibit normal adiponectin levels

increased circulating leptin level ( J:208508 )

• at 25 weeks in mice fed a high fat, high sucrose diet

increased circulating cholesterol level ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased circulating LDL cholesterol level ( J:208508 )

• small density LDL in mice fed a high fat, high sucrose diet

insulin resistance ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased liver triglyceride level ( J:208508 )

• in mice fed a high fat, high sucrose diet

adipose tissue

abnormal fat cell morphology ( J:208508 )

• increased crown-like structure in adipocytes of mice fed a high fat, high sucrose diet

increased fat cell size ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased epididymal fat pad weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

growth/size/body

increased body weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased liver weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

liver/biliary system

increased liver weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased liver triglyceride level ( J:208508 )

• in mice fed a high fat, high sucrose diet