About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5566851
Allelic
Composition
Rhotm1.1Eye/Rho+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm1.1Eye mutation (0 available); any Rho mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• progressive loss of photoreceptor neurons
• diminished outer segment length at P21

vision/eye
• mice show an age-related increase in overall autofluorescence and develop a progressively increasing number of diffuse, subretinal, hyperfluorescent dots
• progressive loss of photoreceptor neurons
• diminished outer segment length at P21
• slightly reduced outer nuclear layer thickness at P21
• scotopic a-wave amplitudes are reduced at high-stimulus intensities at P21, indicating desensitization of photoreceptors
• b-wave amplitude is lower, especially at lower intensities, at P100, but normal at P21

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:205477


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/31/2020
MGI 6.15
The Jackson Laboratory