Phenotypes Associated with This Genotype

Genotype
MGI:5566833

• Allelic Composition: Tg(Pbsn-MYC)#Tt/?
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland adenocarcinoma incidence ( J:205395 )

♂ • microinvasive carcinoma cells sprout out of the PIN lesions and form small nests or masses of neoplastic cells in the periglandular stroma

increased prostate intraepithelial neoplasia incidence ( J:205395 )

♂ • the glandular epithelia of prostate lobes exhibit epithelial thickening, tufting, and cribriform formation, enlarged cell size and nuclei with prominent nucleoli, and increased numbers of mitotic and apoptotic figures, indicating prostate intraepithelial neoplasia (PIN)

♂ • the most severe PIN lesions are in the dorsal lobe

endocrine/exocrine glands

abnormal prostate gland morphology ( J:205395 )

♂ • mucinous metaplasia is seen in different prostatic lobes

increased prostate gland adenocarcinoma incidence ( J:205395 )

♂ • microinvasive carcinoma cells sprout out of the PIN lesions and form small nests or masses of neoplastic cells in the periglandular stroma

increased prostate intraepithelial neoplasia incidence ( J:205395 )

♂ • the glandular epithelia of prostate lobes exhibit epithelial thickening, tufting, and cribriform formation, enlarged cell size and nuclei with prominent nucleoli, and increased numbers of mitotic and apoptotic figures, indicating prostate intraepithelial neoplasia (PIN)

♂ • the most severe PIN lesions are in the dorsal lobe

reproductive system

abnormal prostate gland morphology ( J:205395 )

♂ • mucinous metaplasia is seen in different prostatic lobes

increased prostate gland adenocarcinoma incidence ( J:205395 )

♂ • microinvasive carcinoma cells sprout out of the PIN lesions and form small nests or masses of neoplastic cells in the periglandular stroma

increased prostate intraepithelial neoplasia incidence ( J:205395 )

♂ • the glandular epithelia of prostate lobes exhibit epithelial thickening, tufting, and cribriform formation, enlarged cell size and nuclei with prominent nucleoli, and increased numbers of mitotic and apoptotic figures, indicating prostate intraepithelial neoplasia (PIN)

♂ • the most severe PIN lesions are in the dorsal lobe

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:205395