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Phenotypes Associated with This Genotype
Genotype
MGI:5565211
Allelic
Composition
Col6a3tm2.1Chu/Col6a3+
Genetic
Background
B6.129(Cg)-Col6a3tm2.1Chu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col6a3tm2.1Chu mutation (1 available); any Col6a3 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mitochondria from gastrocnemius muscles of 1 month old mice are enlarged and irregularily shaped

muscle
• increase in endomysial matrix at 6 months of age as compared to controls
• collagen fibers in endomysial connective tissue are disorganized
• collagen VI tetramers from mutant fibroblasts can not assemble into long microfibrils, as a result, the amount of collagen VI microfibrils is decreased in the extracellular matrix of mutant fibroblasts
• immunostaining of coronal sections from E17 embryos exhibit an amorphous, rather than a fibrous, pattern of collagen VI
• sarcoplasmic reticula is distended in gastrocnemius muscles of 1 month old mice
• mutants exhibit a wide distribution of muscle fiber sizes
• mice exhibit more small and large fibers at 6 months of age as compared to controls
• myofibers with centrally located nuclei are observed in quadriceps and diaphragm muscles at 1,3, 6 and 12 months of age
• tenocyte organization is disrupted
• extracellular domains containing collage fiber are poorly organized
• tenocyte organization is disrupted
• collagen fibers from tendons of 1 month old mice appear less organized and sparse as compared to controls
• some fibrils are large with cauliflower-like fibril contours and small diameter fibrils
• most abnormal fibrils are in the pericellular regions
• reduced muscle contractile function at 8 months but not 3 months
• twitch contraction force from extensor digitorum longus muscle is reduced
• progressive myopathy

skeleton
• tenocyte organization is disrupted
• extracellular domains containing collage fiber are poorly organized
• tenocyte organization is disrupted
• collagen fibers from tendons of 1 month old mice appear less organized and sparse as compared to controls
• some fibrils are large with cauliflower-like fibril contours and small diameter fibrils
• most abnormal fibrils are in the pericellular regions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Ullrich congenital muscular dystrophy DOID:0050558 OMIM:254090
J:208903


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory