Phenotypes Associated with This Genotype

Genotype
MGI:5564916

• Allelic Composition: Tg(APOC1)1Lmh/Tg(APOC1)1Lmh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

epidermal spongiosis ( J:135501 )

• 90% of mice show mild-to-moderate spongiosis from 6 weeks onward

impaired skin barrier function ( J:135501 )

• 12 week old mutants exhibit a 4-fold increase in transepidermal water loss indicating that skin barrier function is disturbed; an increase is already seen at 3 weeks

• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks diminishes loss of barrier function

skin inflammation ( J:135501 )

• eosinophil, mast cell, CD4+ T cell, and macrophage infiltration into the skin by 6 weeks of age

• treatment with a corticosteroid cream for 3 weeks diminishes the number of granulocytes, macrophages and CD4+ t cells, but had no effect on mast cells

dermatitis ( J:135501 )

• mice develop signs of atopic dermatitis, comprising scaling, lichenification, papules and mild-to-severe excoriations from an age of 6 weeks

• dermatitis is evident in the upper dorsal skin and with age, the head and eyelids become affected

• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks decreases severity of dermatitis

thick dermal layer ( J:135501 )

thick epidermis ( J:135501 )

• epidermal hyperplasia

• treatment with a corticosteroid cream for 3 weeks inhibits epidermal hyperplasia but results in thinning of the epidermis

scaly skin ( J:135501 )

increased pruritus ( J:135501 )

• frequency of scratching and duration at 9 weeks of age is increased and increases further with age

immune system

increased mast cell degranulation ( J:135501 )

• mast cells show degranulation

increased IgE level ( J:135501 )

• serum IgE levels are increased at 12 weeks of age, but not at 8 weeks of age

• from 12 weeks of age, mast cells in the dermis become IgE-positive

skin inflammation ( J:135501 )

• eosinophil, mast cell, CD4+ T cell, and macrophage infiltration into the skin by 6 weeks of age

• treatment with a corticosteroid cream for 3 weeks diminishes the number of granulocytes, macrophages and CD4+ t cells, but had no effect on mast cells

dermatitis ( J:135501 )

• mice develop signs of atopic dermatitis, comprising scaling, lichenification, papules and mild-to-severe excoriations from an age of 6 weeks

• dermatitis is evident in the upper dorsal skin and with age, the head and eyelids become affected

• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks decreases severity of dermatitis

behavior/neurological

excessive scratching ( J:135501 )

• frequency of scratching and duration at 9 weeks of age is increased and increases further with age

hematopoietic system

increased mast cell degranulation ( J:135501 )

• mast cells show degranulation

increased IgE level ( J:135501 )

• serum IgE levels are increased at 12 weeks of age, but not at 8 weeks of age

• from 12 weeks of age, mast cells in the dermis become IgE-positive

homeostasis/metabolism

epidermal spongiosis ( J:135501 )

• 90% of mice show mild-to-moderate spongiosis from 6 weeks onward

impaired skin barrier function ( J:135501 )

• 12 week old mutants exhibit a 4-fold increase in transepidermal water loss indicating that skin barrier function is disturbed; an increase is already seen at 3 weeks

• treatment with 20% petrolatum in cetomacrogolus cream for 3 weeks diminishes loss of barrier function

cellular

increased mast cell degranulation ( J:135501 )

• mast cells show degranulation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:135501