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Phenotypes Associated with This Genotype
Genotype
MGI:5562921
Allelic
Composition
Tg(SERPINA1*E342K)#Slcw/Tg(SERPINA1*E342K)#Slcw
Genetic
Background
involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SERPINA1*E342K)#Slcw mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice show elevations in liver enzymes such as alanine transaminase and aspartate aminotransferase

liver/biliary system
• mice show liver fibrosis around 4 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
alpha 1-antitrypsin deficiency DOID:13372 OMIM:613490
J:208016


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory