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Phenotypes Associated with This Genotype
Genotype
MGI:5560479
Allelic
Composition
Tg(Cela1-luc,Cela1-TAg)#Nzh/0
Genetic
Background
involves: FVB/N
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phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• about 25% of females develop luciferase negative ovarian tumors by 21 to 23 weeks of age
• mice develop acinar cell carcinoma with a latency of 10 to more than 20 weeks of age
• tumors are highly vascularized and necrosis is seen in some areas of tumors
• rapamycin treatment suppresses acinar cell carcinoma development

reproductive system
• about 25% of females develop luciferase negative ovarian tumors by 21 to 23 weeks of age

neoplasm
• about 25% of females develop luciferase negative ovarian tumors by 21 to 23 weeks of age
• mice develop acinar cell carcinoma with a latency of 10 to more than 20 weeks of age
• tumors are highly vascularized and necrosis is seen in some areas of tumors
• rapamycin treatment suppresses acinar cell carcinoma development
• metastatic lesions to the liver and mesenteric fat tissue is seen and at late stages of tumor development, multiple metastatic lesions to fat tissues of the gastrointestinal tract and the reproductive organs are seen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
J:207960


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory