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Phenotypes Associated with This Genotype
Genotype
MGI:5558108
Allelic
Composition
Tg(CMV-SALL4_iB)#Chai/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 60% of mice exhibit polycystic kidneys

behavior/neurological
• 20% of mice show abnormal gait 3 weeks after birth

hematopoietic system
• mice exhibit myelodysplastic syndrome-like features at 6 to 8 months of age
• increase in CFU-GM (myeloid) colony populations
• mild anemia is seen by 2-6 months of age
• bone marrow shows increased cellularity at 2-6 months of age
• bone marrow show an increased myeloid population at 2-6 months of age
• increase in immature cell population on bone marrow
• megakaryocyte dysplastic features such as hypolobulated megakaryoctyes
• increase in BFU-E colony populations
• erythroid dysplastic features such as binucleate erythroid precursors
• presence of nucleated red blood cells
• many atypical and dysplastic white cells, including hypersegmented neutrophils and pseudo-Pelger-Huet-like cells
• hypersegmented neutrophils
• neutropenia is seen by 2-6 months of age
• leukopenia is seen by 2-6 months of age

neoplasm
• 50% of mice progress to acute myeloid leukemia
• leukemic infiltration is seen in many organs, including lungs, kidneys, liver, spleen, and lymph nodes
• leukemia blast cells are CD34+ and are of myeloid in origin

immune system
• mice exhibit myelodysplastic syndrome-like features at 6 to 8 months of age
• increase in CFU-GM (myeloid) colony populations
• many atypical and dysplastic white cells, including hypersegmented neutrophils and pseudo-Pelger-Huet-like cells
• hypersegmented neutrophils
• neutropenia is seen by 2-6 months of age
• leukopenia is seen by 2-6 months of age

nervous system
• 20% of mice show hydrocephalus 3 weeks after birth that is associated with abnormal gait

renal/urinary system
• 60% of mice exhibit polycystic kidneys

cellular
• binucleate erythroid precursors
• an increase in apoptosis is seen in primary bone marrow and colony-formation assays


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory