Phenotypes Associated with This Genotype

Genotype
MGI:5558082

• Allelic Composition: Bpifa1^m1Ingm/Bpifa1^m1Ingm
• Genetic Background: involves: C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to otitis media ( J:221346 )

• 30.8% of 10-18 month old mice devlop otitis media, associated with mucopurulent material completely or partially filling the middle ear lumen

• otitis is generally unilateral

• increase in polymorphonuclear neutrophil recruitment to the middle ear lumen, accompanied by greater numbers of macrophages and increased cell debris

• mice show signs of chronic otitis media indicated by frequent remodeling of the middle ear epithelium characterized by epithelial hyperplasia, polyps, and thickening of the middle ear mucosa

• source of inflammation in the middle ear is unclear as middle ears are negative for bacterial and fungal pathogens

• however, Eustachian tubes appear normal

increased interleukin-1 alpha secretion ( J:195535 )

• in the bronchoalveolar lavage fluid of mice challenged with K. pneumonia

increased interleukin-1 beta secretion ( J:195535 )

• in the bronchoalveolar lavage fluid of mice challenged with K. pneumonia

increased tumor necrosis factor secretion ( J:195535 )

• in the bronchoalveolar lavage fluid of mice challenged with K. pneumonia

lung inflammation ( J:195535 )

• severe in mice challenged with K. pneumonia

increased susceptibility to bacterial infection ( J:195535 )

• mice exhibit increased susceptibility to K. pneumonia with higher bacterial colony forming units in bronchoalveolar lavage fluid and lungs, increased neutrophil infiltration, increased cytokine (TNFalpha, IL1A, IL1B) and chemokine production and severe pneumonia compared with wild-type mice

hearing/vestibular/ear

increased susceptibility to otitis media ( J:221346 )

• 30.8% of 10-18 month old mice devlop otitis media, associated with mucopurulent material completely or partially filling the middle ear lumen

• otitis is generally unilateral

• increase in polymorphonuclear neutrophil recruitment to the middle ear lumen, accompanied by greater numbers of macrophages and increased cell debris

• mice show signs of chronic otitis media indicated by frequent remodeling of the middle ear epithelium characterized by epithelial hyperplasia, polyps, and thickening of the middle ear mucosa

• source of inflammation in the middle ear is unclear as middle ears are negative for bacterial and fungal pathogens

• however, Eustachian tubes appear normal

respiratory system

respiratory system phenotype ( J:195535 )

N • mice exhibit normal susceptibility to spontaneous development of lung disease or infection and normal lung structure

lung inflammation ( J:195535 )

• severe in mice challenged with K. pneumonia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:221346