Phenotypes Associated with This Genotype

Genotype
MGI:5556129

• Allelic Composition: Mastl^tm1.1Mama/Mastl^tm1.1Mama
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitosis ( J:201971 )

• mitotic aberrations in prometaphase, including defective chromosome condensation and abnormal spindles in primary MEFs following acute expression of cre

• about 75% of MEFs display mitotic arrest following acute expression of cre

• duration of mitosis is increased in primary MEFs following acute expression of cre

• however, no differences in the kinetics of mitotic entry are detected and the function of the spindle assembly checkpoint appears normal in primary MEFs following acute expression of cre

abnormal mitotic spindle morphology ( J:201971 )

decreased fibroblast proliferation ( J:201971 )

• in primary MEFs following acute expression of cre