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Phenotypes Associated with This Genotype
Genotype
MGI:5556128
Allelic
Composition		 Mastltm1.1Mama/Mastltm1.1Mama
Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mastltm1.1Mama mutation (0 available); any Mastl mutation (36 available)
Polr2atm1(cre/ERT2)Bbd mutation (3 available); any Polr2a mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:201971 )
• following treatment with tamoxifen at E12.5, at E14.5 an increase in mitotic figures is seen in the neuroepithelium
• mitotic figures display an accumulation of prometaphases/metaphases

embryo
abnormal embryonic neuroepithelium morphology ( J:201971 )
• following treatment with tamoxifen at E12.5, at E14.5 an increase in mitotic figures is seen in the neuroepithelium

nervous system
abnormal embryonic neuroepithelium morphology ( J:201971 )
• following treatment with tamoxifen at E12.5, at E14.5 an increase in mitotic figures is seen in the neuroepithelium

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory