Phenotypes Associated with This Genotype

Genotype
MGI:5555966

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-Rai1,-EGFP)463Walz/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:207141 )

• mutants start to show lower weight at 4 months of age

behavior/neurological

impaired contextual conditioning behavior ( J:207141 )

• mutants show less freezing in the contextual fear test, indicating that learning and/or memory are impaired

impaired cued conditioning behavior ( J:207141 )

• mutants show less freezing in the sound cued fear tests, indicating that learning and/or memory are impaired

increased locomotor activity ( J:207141 )

• in the open field, mutants show an increase in total distance traveled indicating hyperactivity

• however, anxiety-like behavior is not observed and mice show normal sociability and preference for social novelty

decreased vocalization ( J:207141 )

• lower percentage of vocalization, with mutants showing 17% vocalization compared to 29% in wild-type mice

adipose tissue

decreased abdominal fat pad weight ( J:207141 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Potocki-Lupski syndrome		DOID:0060853	OMIM:610883	J:207141