Phenotypes Associated with This Genotype

Genotype
MGI:5552012

• Allelic Composition: Sox10^tm1Weg/Sox10⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:67383 )

• in the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice, a significant proportion of heterozygotes are lost during the first postnatal weeks; at weaning, only 38.2% of heterozygotes are seen instead of the expected 50% but expected numbers are seen perinatally

digestive/alimentary system

megacolon ( J:67383 )

• a fraction of heterozygotes from the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice exhibit megacolon

integument

belly spot ( J:67383 )

• in the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice, heterozygotes display a white belly spot

pigmentation

belly spot ( J:67383 )

• in the fourth or subsequent generations of backcrosses with C3HeB/FeJ mice, heterozygotes display a white belly spot

decreased melanocyte number ( J:67383 )

• melanocytes are reduced in numbers in mice from the fourth or subsequent generations of backcrosses with C3HeB/FeJ