Phenotypes Associated with This Genotype

Genotype
MGI:5551604

• Allelic Composition: Krt9^{tm1(KOMP)Vlcg}/Krt9^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6J * C57BL/6NTac
• Cell Lines: 10313A-C10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased keratinocyte proliferation ( J:206051 )

• in the footpad

hyperkeratosis ( J:206051 )

• localized on the fore- and hindpaw footpads and digits

• however, the inter-footpad plantar epidermis is not hyperkeratotic

abnormal epidermis stratum granulosum morphology ( J:206051 )

• impaired keratinocyte flattening with larger, abnormally shaped and nucleated keratinocytes

abnormal epidermis stratum spinosum morphology ( J:206051 )

• general lack of keratin intermediate filaments in spinous layer keratinocytes

acanthosis ( J:206051 )

• localized on the fore- and hindpaw footpads

abnormal keratinocyte morphology ( J:206051 )

• larger, abnormally shaped and nucleated keratinocytes in the epidermis stratum granulosum

• general lack of keratin intermediate filaments in spinous layer keratinocytes

• however, desmosomes are normal

thick epidermis ( J:206051 )

• on the footpad

abnormal skin appearance ( J:206051 )

• hyperpigmented calluses on the rear, stress-bearing forepaw footpad beginning between 3 and 4 weeks of age

• calluses develop on minor footpad of both fore- and hindpaws

• calluses worsen with age

blistering ( J:206051 )

• forepaw footpad skin

pallor ( J:206051 )

• widespread in the spinous layer keratinocytes

thick skin ( J:206051 )

• forepaw footpad skin

increased skin papilloma incidence ( J:206051 )

• papillomatous epidermis on the footpad

limbs/digits/tail

abnormal foot pad morphology ( J:206051 )

• calluses develop on minor footpad of both fore- and hindpaws

• localized acanthosis and hyperkeratosis on the fore- and hindpaw footpads

• thickened (3 times) and papillomatous epidermis

• footpads are larger with uneven, rough surface and significant fissures compared with in wild-type mice

pigmentation

hyperpigmentation ( J:206051 )

• hyperpigmented calluses on the rear, stress-bearing forepaw footpad beginning between 3 and 4 weeks of age

neoplasm

increased skin papilloma incidence ( J:206051 )

• papillomatous epidermis on the footpad

cellular

increased keratinocyte proliferation ( J:206051 )

• in the footpad

behavior/neurological

behavior/neurological phenotype ( J:206051 )

N • mice exhibit normal mobility

growth/size/body

growth/size/body region phenotype ( J:206051 )

N • mice exhibit normal ability to thrive