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Phenotypes Associated with This Genotype
Genotype
MGI:5548208
Allelic
Composition
Tg(Vav1-ERG)#Jpim/0
Genetic
Background
involves: C57BL/6
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See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

neoplasm
• all mice develop acute leukemia (J:174808)
• all other mice that do not have T-ALL develop myeloid leukemia, showing massive infiltration of leukemic blasts into the bone marrow, the spleen, and the liver, anemia, and thrombocytopenia (J:203438)
• leukemic cells are lineage negative and c-Kit+Sca-1-CD150+, characteristic of megakaryocyte-erythroid progenitors and gene expression and binding analysis show that these leukemias show a transcriptional program similar to human acute myeloid leukemia (J:203438)
• the Pim1 inhibitor SGI-1776 inhibits leukemia cell growth and induces apoptosis in these cells (J:203438)
• immunophenotype of the T-ALL blasts is cKit-CD3+CD8+CD4- (J:174808)
• approximately 30% of leukemias are characterized as T-acute lymphoblastic leukemia (T-ALL) (J:174808)
• about 30% of mice develop T-ALL (J:203438)

mortality/aging
• all mice that develop T-ALL die by 7 months of age with a median survival age of 20 weeks (J:174808)
• all mice that do not develop and die from T-ALL, die from myeloid leukemia by 5 months of age (J:203438)

hematopoietic system
• dense infiltration of thymus with lymphoblasts and almost complete disorganization of the tissue architecture

immune system
• dense infiltration of thymus with lymphoblasts and almost complete disorganization of the tissue architecture

endocrine/exocrine glands
• dense infiltration of thymus with lymphoblasts and almost complete disorganization of the tissue architecture

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:203438


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory