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Phenotypes Associated with This Genotype
Genotype
MGI:5547758
Allelic
Composition
Tg(Utg-TAg)7736Fjd/?
Genetic
Background
involves: FVB
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phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• succumb at 16-20 weeks

respiratory system
• mutants develop multifocal pulmonary adenocarcinoma of the lung and succumb at 16-20 weeks of age
• bronchiolar epithelium shows areas of hyperplasia by 2 months of age, tumor foci are seen at 3 months and majority of lung is composed of transformed cells 4 weeks later
• areas of hyperplasia of the bronchiolar epithelium are seen by 2 months of age

neoplasm
• mutants develop multifocal pulmonary adenocarcinoma of the lung and succumb at 16-20 weeks of age
• bronchiolar epithelium shows areas of hyperplasia by 2 months of age, tumor foci are seen at 3 months and majority of lung is composed of transformed cells 4 weeks later

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:70785


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory