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Phenotypes Associated with This Genotype
Genotype
MGI:5547498
Allelic
Composition		 ApcMin/Apc+
Hsd11b2tm1.1Mzz/Hsd11b2tm1.1Mzz
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Hsd11b2tm1.1Mzz mutation (1 available); any Hsd11b2 mutation (19 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:205456 )
• fewer total intestinal adenoma at 20 weeks with prevented initiation of polyp formation compared with ApcMin heterozygotes
decreased tumor growth/size ( J:205456 )
• reduced proliferation and increased apoptosis compared with tumors from ApcMin heterozygotes

homeostasis/metabolism
abnormal corticosterone level ( J:205456 )
• 10-fold higher corticosterone (active glucocorticoid) levels in the intestine compared with ApcMin heterozygotes
• 11-keto-corticosterone (inactive glucocorticoid) levels is lower in the intestine compared with ApcMin heterozygotes

digestive/alimentary system
increased intestinal adenoma incidence ( J:205456 )
• fewer total intestinal adenoma at 20 weeks with prevented initiation of polyp formation compared with ApcMin heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory