Phenotypes Associated with This Genotype

Genotype
MGI:5546331

• Allelic Composition: Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Skeletal muscle abnormalities in Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl and Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl mice

limbs/digits/tail

abnormal limb muscle morphology ( J:201148 )

♂ • the triceps is least effected with a 5% decrease in weight

decreased quadriceps weight ( J:201148 )

♂ • the quadriceps is most the most effected muscle with a 12% in weight

muscle

abnormal limb muscle morphology ( J:201148 )

♂ • the triceps is least effected with a 5% decrease in weight

decreased quadriceps weight ( J:201148 )

♂ • the quadriceps is most the most effected muscle with a 12% in weight

decreased skeletal muscle weight ( J:201148 )

♂ • decrease of 5-12% in muscle weight in males at 10 weeks of age

abnormal skeletal muscle fiber type ratio ( J:201148 )

• seems to be a shift in fiber type from fast glycolytic type IIb fibers to fast oxidative type IIa fibers in the gastrocnemius muscle

impaired skeletal muscle regeneration ( J:201148 )

• impaired regeneration following cardiotoxin induced injury of the gastrocnemius muscle

skeleton

skeleton phenotype ( J:201148 )

N • no skeletal defects