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Phenotypes Associated with This Genotype
Genotype
MGI:5544915
Allelic
Composition
Tg(HBVX*,-Myc)#Skp/Tg(HBVX*,-Myc)#Skp
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• progressive liver enlargement with a most noticeable increase from 20 weeks
• increase in liver weight, that is most noticeable after 20 weeks of life

liver/biliary system
• liver begins to appear nodular, congested and firm in consistency at 28 weeks of age
• liver begins to appear congested at 28 weeks of age
• focal necrosis is seen about 8-12 weeks of age
• progressive liver enlargement with a most noticeable increase from 20 weeks
• increase in liver weight, that is most noticeable after 20 weeks of life
• abundant glycogen is seen in hepatocytes up to 4 weeks of age, which then gradually diminishes and remains periportal in location, unlike in controls which show glycogen at all stages
• iron is seen in the dysplastic hepatocytes around the central veins but not in tumor cells
• expansion of hepatic lobules with a clustering of large numbers of central veins in a given field with spaced out portal tracts at the periphery from 4 weeks of age onwards
• apoptotic bodies are seen scattered in the sinusoids
• cytological changes in hepatocytes start as early as day 3 and show swelling, an increase in proliferation accompanied by a high rate of apoptosis which declines once tumors form
• from day 7, hepatocytes show progressive nuclear enlargement, vesicular chromatin, prominent, single or multiple nucleoli, nuclear pleomorphism, and typical and atypical mitosis
• by day 14, nuclear enlargement is seen, some with abnormal contours, while cytoplasm contains numerous mitochondria including abnormal forms
• cytoplasm of hepatocytes becomes more basophilic after 4 weeks
• abundant glycogen is seen in hepatocytes up to 4 weeks of age, which then gradually diminishes and remains periportal in location, unlike in controls which show glycogen at all stages
• iron is seen in the dysplastic hepatocytes around the central veins but not in tumor cells
• mild microvesicular fatty change in the hepatocytes around the central veins at weeks 4-5
• however, cirrhosis is not seen
• multiple tumor nodules are seen on the surface of the liver between 28 and 32 weeks
• tumor nodules show central necrosis
• between 24-32 weeks of age, multifocal, well-differentiated, hepatocellular carcinoma with a trabecular pattern emerges
• malignant hepatocyte cords show large pleomorphic nuclei with multinucleation and macronucleoli
• by 16-20 weeks, multiple dysplastic foci are incorporated into distinct neoplastic nodules that compress the surrounding liver parenchyma and nodules show compressed reticulin at the periphery

neoplasm
• multiple tumor nodules are seen on the surface of the liver between 28 and 32 weeks
• tumor nodules show central necrosis
• between 24-32 weeks of age, multifocal, well-differentiated, hepatocellular carcinoma with a trabecular pattern emerges
• malignant hepatocyte cords show large pleomorphic nuclei with multinucleation and macronucleoli
• by 16-20 weeks, multiple dysplastic foci are incorporated into distinct neoplastic nodules that compress the surrounding liver parenchyma and nodules show compressed reticulin at the periphery

cardiovascular system
• apoptotic bodies are seen scattered in the sinusoids
• liver begins to appear congested at 28 weeks of age

hematopoietic system
• livers show an early disappearance of foci of extramedullary hematopoiesis in the portal tracts by day 14 compared to controls which show persistence of extramedullary hematopoiesis by the 4th week
• Kupffer cells appear prominent between 4 and 12 weeks of age

homeostasis/metabolism
• abundant glycogen is seen in hepatocytes up to 4 weeks of age, which then gradually diminishes and remains periportal in location, unlike in controls which show glycogen at all stages
• iron is seen in the dysplastic hepatocytes around the central veins but not in tumor cells

immune system
• Kupffer cells appear prominent between 4 and 12 weeks of age

cellular
• liver shows an increase in the number of nucleolar organizer regions
• focal necrosis is seen about 8-12 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:81098 , J:202732


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory