Phenotypes Associated with This Genotype

Genotype
MGI:5544581

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt; Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung vasculature morphology ( J:204743 )

• in absence of lung formation, the pulmonary vascular plexus persists throughout embryonic development, but does not branch or develop further

tracheoesophageal fistula ( J:153098 )

abnormal lung development ( J:204743 )

• lungs fail to develop from the foregut

absent lungs ( J:204743 )

• lung agenesis is found in embryos examined at E13.5 and E17.5

cardiovascular system

cardiovascular system phenotype ( J:204743 )

N • although no lungs develop, heart development and outflow and inflow tract structures are relatively normal, including atrial septation, septation between aorta and the pulmonary trunk, and atrioventricular canal development

abnormal pulmonary artery morphology ( J:204743 )

• primitive non-branched pulmonary arteries which flank the esophagus and originate from the pulmonary trunk persist in E17.5 embryos

• pulmonary veins and pulmonary arteries develop and intersect at approximate location where a lung bud would be present in a normal embryo

abnormal lung vasculature morphology ( J:204743 )

• in absence of lung formation, the pulmonary vascular plexus persists throughout embryonic development, but does not branch or develop further

abnormal pulmonary vein morphology ( J:204743 )

digestive/alimentary system

tracheoesophageal fistula ( J:153098 )