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Phenotypes Associated with This Genotype
Genotype
MGI:5543910
Allelic
Composition
Tg(Amh-SMAD2*)#Jebu/0
Genetic
Background
FVB/N-Tg(Amh-SMAD2*)#Jebu
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mutants develop ovarian inclusion cysts; mice that only develop inclusion cysts show low transgene expression

endocrine/exocrine glands
• mutants develop ovarian inclusion cysts; mice that only develop inclusion cysts show low transgene expression
• 3 of 18 mutants exhibit abnormal tumor-like ovaries at 8 weeks of age, with tumors showing some, but not all the characteristics of the mature teratomas
• 5 of 18 mutants develop ovarian teratomas at 2-6 months of age, some of which appear malignant; mice that develop teratomas show high transgene expression
• teratomas are characterized by areas of invasive, undifferentiated cells and inclusion cysts lined with ciliated cells reminiscent of oviductal or respiratory epithelium
• 3 of the tumors contain squamous cell-lined cysts filled with keratin and well-to-moderately differentiated invasive squamous cells and nervous tissue-like areas
• fat, blood-filled spaces, calcified bone and cartilage formation, and thyroid gland-like structures are seen in some teratomas
• by 6 months of age, teratomas are about 10 times the size of a normal ovary, do not show normal follicular or ovarian structures, and contain many highly proliferative epithelium-lined inclusion cysts

reproductive system
• mutants develop ovarian inclusion cysts; mice that only develop inclusion cysts show low transgene expression
• 3 of 18 mutants exhibit abnormal tumor-like ovaries at 8 weeks of age, with tumors showing some, but not all the characteristics of the mature teratomas
• 5 of 18 mutants develop ovarian teratomas at 2-6 months of age, some of which appear malignant; mice that develop teratomas show high transgene expression
• teratomas are characterized by areas of invasive, undifferentiated cells and inclusion cysts lined with ciliated cells reminiscent of oviductal or respiratory epithelium
• 3 of the tumors contain squamous cell-lined cysts filled with keratin and well-to-moderately differentiated invasive squamous cells and nervous tissue-like areas
• fat, blood-filled spaces, calcified bone and cartilage formation, and thyroid gland-like structures are seen in some teratomas
• by 6 months of age, teratomas are about 10 times the size of a normal ovary, do not show normal follicular or ovarian structures, and contain many highly proliferative epithelium-lined inclusion cysts

neoplasm
• 3 of 18 mutants exhibit abnormal tumor-like ovaries at 8 weeks of age, with tumors showing some, but not all the characteristics of the mature teratomas
• 5 of 18 mutants develop ovarian teratomas at 2-6 months of age, some of which appear malignant; mice that develop teratomas show high transgene expression
• teratomas are characterized by areas of invasive, undifferentiated cells and inclusion cysts lined with ciliated cells reminiscent of oviductal or respiratory epithelium
• 3 of the tumors contain squamous cell-lined cysts filled with keratin and well-to-moderately differentiated invasive squamous cells and nervous tissue-like areas
• fat, blood-filled spaces, calcified bone and cartilage formation, and thyroid gland-like structures are seen in some teratomas
• by 6 months of age, teratomas are about 10 times the size of a normal ovary, do not show normal follicular or ovarian structures, and contain many highly proliferative epithelium-lined inclusion cysts

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dermoid cyst of ovary DOID:5117 OMIM:166950
J:200783


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory