Phenotypes for Bub1b MGI:5543390 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bub1b^tm1.1Hsl/Bub1b^tm1.1Hsl
Genetic Background	involves: 129 * C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1b^tm1.1Hsl mutation (0 available); any Bub1b mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice die at approximately E6.5

embryo

abnormal embryo development ( J:201641 )

• 4 of 17 E6.5 mice exhibit abnormal morphology with massive TUNEL staining

embryonic growth retardation ( J:201641 )

• of some cultured E3.5 embryos

cellular

increased apoptosis ( J:201641 )

• 4 of 17 E6.5 mice exhibit abnormal morphology with massive TUNEL staining

growth/size/body

embryonic growth retardation ( J:201641 )

• of some cultured E3.5 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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