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Phenotypes Associated with This Genotype
Genotype
MGI:5538655
Allelic
Composition
Pgap3tm1.1Ymra/Pgap3tm1.1Ymra
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgap3tm1.1Ymra mutation (0 available); any Pgap3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• following Thy-1 cross-linking when TCR signaling is absent
• when TCR signaling is optimal with increasing concentration of anti-Thy1 antibody
• enhanced alloresponse and antigen-primed response of CD4+ T cells

mortality/aging

reproductive system
N
• male and female mice are fertile

immune system
N
• T cell development is normal
• following Thy-1 cross-linking when TCR signaling is absent
• when TCR signaling is optimal with increasing concentration of anti-Thy1 antibody
• enhanced alloresponse and antigen-primed response of CD4+ T cells
• glycosylphosphatidylinositol-anchored protein (GPI-AP) without fatty acid remodeling fail to associate with lipid rafts in T cells
• enhanced antigen-primed response of CD4+ T cells
• in some mice with severe paralysis and death within 4 weeks after MOG induction
• however, the overall clinical score is normal

limbs/digits/tail
• kinked tails

growth/size/body
• short head

behavior/neurological
• in some mice treated with MOG

hematopoietic system
• following Thy-1 cross-linking when TCR signaling is absent
• when TCR signaling is optimal with increasing concentration of anti-Thy1 antibody
• enhanced alloresponse and antigen-primed response of CD4+ T cells
• glycosylphosphatidylinositol-anchored protein (GPI-AP) without fatty acid remodeling fail to associate with lipid rafts in T cells
• enhanced antigen-primed response of CD4+ T cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory