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Phenotypes Associated with This Genotype
Genotype
MGI:5538583
Allelic
Composition
Tg(MMTV-Erbb2)NK1Mul/0
Genetic
Background
FVB/N-Tg(MMTV-Erbb2)NK1Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• about 20% of mutants develop mammary tumors by the 25th week of age, and by the 30th week, tumor incidence increases to 83%
• high dose of flaxseed oil (with a an omega6:omega3 fatty acid ratio of about 1) results in some delay in the growth of mammary tumors, however low and mid doses with omega6:omega3 ratios of 7.7 and 3.1 enhance tumor development
• melatonin treatment delays the appearance of palpable tumors
• combination of both flaxseed oil and melatonin results in a slight delay of tumor development, similar that seen with melatonin only

integument
• about 20% of mutants develop mammary tumors by the 25th week of age, and by the 30th week, tumor incidence increases to 83%
• high dose of flaxseed oil (with a an omega6:omega3 fatty acid ratio of about 1) results in some delay in the growth of mammary tumors, however low and mid doses with omega6:omega3 ratios of 7.7 and 3.1 enhance tumor development
• melatonin treatment delays the appearance of palpable tumors
• combination of both flaxseed oil and melatonin results in a slight delay of tumor development, similar that seen with melatonin only

endocrine/exocrine glands
• about 20% of mutants develop mammary tumors by the 25th week of age, and by the 30th week, tumor incidence increases to 83%
• high dose of flaxseed oil (with a an omega6:omega3 fatty acid ratio of about 1) results in some delay in the growth of mammary tumors, however low and mid doses with omega6:omega3 ratios of 7.7 and 3.1 enhance tumor development
• melatonin treatment delays the appearance of palpable tumors
• combination of both flaxseed oil and melatonin results in a slight delay of tumor development, similar that seen with melatonin only

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:67457


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory