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Phenotypes Associated with This Genotype
Genotype
MGI:5538529
Allelic
Composition
Smarcb1tm1Sho/Smarcb1+
Tg(LPV-TAg121)2Tvd/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcb1tm1Sho mutation (0 available); any Smarcb1 mutation (10 available)
Tg(LPV-TAg121)2Tvd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• malignant rhabdoid tumors develop with increased frequency (55%) and reduced latency (median, 4.9 months) compared to single Smarcb1 heterozygotes
• both soft tissue and CNS tumor frequencies increase (32% and 24%, respectively)
• 44% of malignant rhabdoid tumors are located around the roots or spinal nerves within the spinal cord, most frequently near the thoracolumbar junction with a median age of 5.2 months
• malignant rhabdoid tumors have a more than a 4-fold increase in mitotic index compared with single Smarcb1 heterozygotes
• 100% penetrance of choroid plexus carcinomas, with a median latency of 9 months, similar to single Tg(LPV-TAg121)2Tvd mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory