Mouse Genome Informatics
involves: CD-1
phenotype observed in females
phenotype observed in males
N normal phenotype
• food-restricted males habituate more quickly than wild-type males
• food-restricted females habituate more slowly than wild-type females
• mutants are slower to learn to press the lever for food compared to wild-type mice indicating impaired learning of an autoshaping task
• however, mutants exhibit normal behavior on a vigilance task in an operant chamber and on an operant go/no-go task measuring sustained attention and impulsivity
• food-restricted males rear less than wild-type mice
• males, but not females, rear more than wild-type controls
• males, but not females, are more active than wild-type controls in open-field activity
• food-restricted males exhibit reduced activity in the open-field compared to free-feeding activity levels

Mouse Models of Human Disease
Attention Deficit-Hyperactivity Disorder; ADHD 143465 J:128754