Mouse Genome Informatics
tg
    Tg(ACTB-THRB*)#Syc/0
involves: CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• food-restricted males habituate more quickly than wild-type males
• food-restricted females habituate more slowly than wild-type females
• mutants are slower to learn to press the lever for food compared to wild-type mice indicating impaired learning of an autoshaping task
• however, mutants exhibit normal behavior on a vigilance task in an operant chamber and on an operant go/no-go task measuring sustained attention and impulsivity
• food-restricted males rear less than wild-type mice (J:128754)
• males, but not females, are more active than wild-type controls in open-field activity (J:128754)
• food-restricted males exhibit reduced activity in the open-field compared to free-feeding activity levels (J:128754)
• males, but not females, rear more than wild-type controls (J:128754)

Mouse Models of Human Disease
OMIM IDRef(s)
Attention Deficit-Hyperactivity Disorder; ADHD 143465 J:128754