Mouse Genome Informatics
cx
    Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+
Tg(Scgb1a1-rtTA)1Jaw/0

involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• doxycycline-treated mice exhibit a median survival of 7 to 8 weeks

tumorigenesis
• withdrawal of doxycycline leads to complete tumor regression
• ALK kinase inhibitor is a more effective therapy than chemotherapy in doxycycline-treated mice
• doxycycline-treated mice develop lung tumorigenesis with a latency of less than 10 days
• however, withdrawal of doxycycline leads to complete tumor regression
• adenocarcinomas predominantly bronchioloalveolar carcinoma with occasional pleural space and airway invasion by an acinar component in doxycycline-treated mice

growth/size/body
• in tumor-bearing, doxycycline-treated mice in the first 4 weeks

respiratory system
N
• untreated mice exhibit normal lung histology (J:166724)

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:166724