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Phenotypes Associated with This Genotype
Genotype
MGI:5527317
Allelic
Composition
Tg(MMTV-ERBB2)5Erick/?
Genetic
Background
FVB/N-Tg(MMTV-ERBB2)5Erick
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 76% of females develop asynchronous mammary tumors with an average latency of 28.2 weeks, with the earliest onset at 23 weeks of age
• females treated with an anti-ERBB2 antibody, mu4D5, show reduced mammary tumor incidence and inhibition of tumor growth
• tumors exhibit features of rapidly growing adenocarcinoma with areas of solid, tubular, and papillary growth, cellular pleomorphism, and mitotic activity
• the enlarged Harderian glands show residual normal-appearing acinar tissue adjacent to circumscribed areas of adenomatous growth, with these areas showing effacement of the normal glandular architecture with solid and papillary growth and showing resemblance to Harderian gland adenoma, acinar type
• Hardarian gland neoplasms are not seen in females treated early with an anti-ERBB2 antibody, mu4D5
• pulmonary metastases are seen

endocrine/exocrine glands
• 76% of females develop asynchronous mammary tumors with an average latency of 28.2 weeks, with the earliest onset at 23 weeks of age
• females treated with an anti-ERBB2 antibody, mu4D5, show reduced mammary tumor incidence and inhibition of tumor growth
• tumors exhibit features of rapidly growing adenocarcinoma with areas of solid, tubular, and papillary growth, cellular pleomorphism, and mitotic activity
• enlarged Harderian gland, especially in aging mice that have yet to develop mammary tumors
• the enlarged Harderian glands show residual normal-appearing acinar tissue adjacent to circumscribed areas of adenomatous growth, with these areas showing effacement of the normal glandular architecture with solid and papillary growth and showing resemblance to Harderian gland adenoma, acinar type
• Hardarian gland neoplasms are not seen in females treated early with an anti-ERBB2 antibody, mu4D5

vision/eye
• progressive exopthalamus due to Harderian gland neoplasms

integument
• 76% of females develop asynchronous mammary tumors with an average latency of 28.2 weeks, with the earliest onset at 23 weeks of age
• females treated with an anti-ERBB2 antibody, mu4D5, show reduced mammary tumor incidence and inhibition of tumor growth
• tumors exhibit features of rapidly growing adenocarcinoma with areas of solid, tubular, and papillary growth, cellular pleomorphism, and mitotic activity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:90202


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory