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Phenotypes Associated with This Genotype
Genotype
MGI:5524146
Allelic
Composition
Tg(MMTV-Myc*T58A)TA39Jrn/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop mammary tumors but tumor burden is reduced compared to the other transgenic lines, with the majority of mice harboring only a single tumor
• Kras activating mutations are seen in 22.2% of tumors
• majority of tumors are either squamous or epithelial-mesenchymal-transition (EMT) type tumors but microacinar, papillary, solid, and mixed type tumors are also seen
• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors

integument
• mice develop mammary tumors but tumor burden is reduced compared to the other transgenic lines, with the majority of mice harboring only a single tumor
• Kras activating mutations are seen in 22.2% of tumors
• majority of tumors are either squamous or epithelial-mesenchymal-transition (EMT) type tumors but microacinar, papillary, solid, and mixed type tumors are also seen
• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors

endocrine/exocrine glands
• mice develop mammary tumors but tumor burden is reduced compared to the other transgenic lines, with the majority of mice harboring only a single tumor
• Kras activating mutations are seen in 22.2% of tumors
• majority of tumors are either squamous or epithelial-mesenchymal-transition (EMT) type tumors but microacinar, papillary, solid, and mixed type tumors are also seen
• EMT subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:193362


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory