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Phenotypes Associated with This Genotype
Genotype
MGI:5524085
Allelic
Composition
Tg(MMTV-Myc)WT21Jrn/0
Genetic
Background
involves: FVB/N
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See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mutants develop mammary tumors (J:153233)
• nearly 40% of mammary tumors are microacinar, with the remainder of tumors showing various other morphologies including, papillary, squamous, epithelial-mesenchymal-transition (EMT) type, solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)
• the squamous/EMT subgroup of tumors shares attributes of human triple-negative breast cancer and is associated with an increase in risk of metastasis (J:153233)
• Kras mutations are seen in 25.6% of tumors (J:193362)
• mice with tumors containing a Kras mutation show a reduction in latency compared to mice with tumors without a mutation (J:193362)
• microacinar type tumors show similar expression profiles to human luminal B tumors (J:193362)
• epithelial-mesenchymal-transition (EMT) subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)
• pulmonary metastasis is sometimes observed and is associated with the squamous/EMT subgroup of tumors

integument
• mutants develop mammary tumors (J:153233)
• nearly 40% of mammary tumors are microacinar, with the remainder of tumors showing various other morphologies including, papillary, squamous, epithelial-mesenchymal-transition (EMT) type, solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)
• the squamous/EMT subgroup of tumors shares attributes of human triple-negative breast cancer and is associated with an increase in risk of metastasis (J:153233)
• Kras mutations are seen in 25.6% of tumors (J:193362)
• mice with tumors containing a Kras mutation show a reduction in latency compared to mice with tumors without a mutation (J:193362)
• microacinar type tumors show similar expression profiles to human luminal B tumors (J:193362)
• epithelial-mesenchymal-transition (EMT) subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

endocrine/exocrine glands
• mutants develop mammary tumors (J:153233)
• nearly 40% of mammary tumors are microacinar, with the remainder of tumors showing various other morphologies including, papillary, squamous, epithelial-mesenchymal-transition (EMT) type, solid, adenocarcinoma and tumors with mixed population of various types of tumors (J:153233)
• the squamous/EMT subgroup of tumors shares attributes of human triple-negative breast cancer and is associated with an increase in risk of metastasis (J:153233)
• Kras mutations are seen in 25.6% of tumors (J:193362)
• mice with tumors containing a Kras mutation show a reduction in latency compared to mice with tumors without a mutation (J:193362)
• microacinar type tumors show similar expression profiles to human luminal B tumors (J:193362)
• epithelial-mesenchymal-transition (EMT) subtype tumors have an elevation in the frequency of activating Kras mutations compared to the other types of tumors seen in mutants and show similar expression profiles to human claudin-low tumors (J:193362)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:193362


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory