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Phenotypes Associated with This Genotype
Genotype
MGI:5523996
Allelic
Composition
Scn1atm1Kea/Scn1a+
Genetic
Background
(C57BL/6J x 129S6/SvEvTac-Scn1atm1Kea)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm1Kea mutation (1 available); any Scn1a mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: mice on a background containing C57BL/6J exhibit premature death with 50% of mice dying by 1 month of age unlike mice on a coisogenic 129S6/SvEvTac background

behavior/neurological
• Background Sensitivity: mice on a background containing C57BL/6J exhibit spontaneous seizures unlike mice on a coisogenic 129S6/SvEvTac background

nervous system
• Background Sensitivity: mice on a background containing C57BL/6J exhibit spontaneous seizures unlike mice on a coisogenic 129S6/SvEvTac background

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Dravet syndrome DOID:0080422 OMIM:607208
J:203040


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory