Mouse Genome Informatics
tg
    Tg(SFTPC-EZR/ROS1)AShiba/0
C57BL/6-Tg(SFTPC-EZR/ROS1)AShiba
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• reduction in survival due to adenocarcinoma

tumorigenesis
• mutants develop lung adenocarcinoma, with mice showing lesions over 1 mm in diameter already at 4 weeks of age and tumors occupy over 40% of lung surface at this time
• lung tumors are adenocarcinomas with papillary/lepidic growth pattern
• distant metastasis is not observed

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:199415