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Phenotypes Associated with This Genotype
Genotype
MGI:5523927
Allelic
Composition
Tg(SFTPC-EZR/ROS1)AShiba/0
Genetic
Background
C57BL/6-Tg(SFTPC-EZR/ROS1)AShiba
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mutants develop lung adenocarcinoma, with mice showing lesions over 1 mm in diameter already at 4 weeks of age and tumors occupy over 40% of lung surface at this time
• lung tumors are adenocarcinomas with papillary/lepidic growth pattern
• distant metastasis is not observed

mortality/aging
• reduction in survival due to adenocarcinoma

neoplasm
• mutants develop lung adenocarcinoma, with mice showing lesions over 1 mm in diameter already at 4 weeks of age and tumors occupy over 40% of lung surface at this time
• lung tumors are adenocarcinomas with papillary/lepidic growth pattern
• distant metastasis is not observed

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:199415


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory