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Phenotypes Associated with This Genotype
Genotype
MGI:5523927
Allelic
Composition
Tg(SFTPC-EZR/ROS1)AShiba/0
Genetic
Background
C57BL/6-Tg(SFTPC-EZR/ROS1)AShiba
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduction in survival due to adenocarcinoma (J:199415)
• reduction in survival due to adenocarcinoma (J:199415)

tumorigenesis
• mutants develop lung adenocarcinoma, with mice showing lesions over 1 mm in diameter already at 4 weeks of age and tumors occupy over 40% of lung surface at this time (J:199415)
• lung tumors are adenocarcinomas with papillary/lepidic growth pattern (J:199415)
• distant metastasis is not observed (J:199415)
• mutants develop lung adenocarcinoma, with mice showing lesions over 1 mm in diameter already at 4 weeks of age and tumors occupy over 40% of lung surface at this time (J:199415)
• lung tumors are adenocarcinomas with papillary/lepidic growth pattern (J:199415)
• distant metastasis is not observed (J:199415)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:199415


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory