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Phenotypes Associated with This Genotype
Genotype
MGI:5523484
Allelic
Composition
Exo1tm2Wed/Exo1tm2Wed
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Exo1tm2Wed mutation (0 available); any Exo1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Decreased testis weight in Exo1tm2Wed/Exo1tm2Wed males

mortality/aging

reproductive system
N
• female mice exhibit normal fertility
• very few spermatogenic cells progress through meiosis II
• very few spermatogenic cells progress through meiosis II
• abnormal metaphase configurations with abnormal spindle structures

neoplasm
• less so than in Exo1tm3.1Wed homozygotes
• in most mice without an increase in microsatellite instability
• less so than in Exo1tm3.1Wed homozygotes

immune system
• mice treated with LPS or LPS and IL4 fail to exhibit efficient class switch recombination from IgM to IgG3 or IgG1 compared with wild-type mice
• splenic B cells from mice immunized with NP-CGG exhibit a decrease in the frequency of mutations at the A:T base pairs in Polh hotspots and a bias towards transition mutations at G:C base pairs compared with wild-type B cells
• however, the overall frequency of mutation is normal

cellular
• very few spermatogenic cells progress through meiosis II
• mouse embryonic fibroblasts exhibit impaired double strand break repair through DNA end resection compared with wild-type cells
• increased mutation frequencies and an increase in transversions

homeostasis/metabolism
• mouse embryonic fibroblasts exhibit impaired double strand break repair through DNA end resection compared with wild-type cells
• increased mutation frequencies and an increase in transversions

endocrine/exocrine glands

hematopoietic system
• mice treated with LPS or LPS and IL4 fail to exhibit efficient class switch recombination from IgM to IgG3 or IgG1 compared with wild-type mice
• splenic B cells from mice immunized with NP-CGG exhibit a decrease in the frequency of mutations at the A:T base pairs in Polh hotspots and a bias towards transition mutations at G:C base pairs compared with wild-type B cells
• however, the overall frequency of mutation is normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory