Phenotypes Associated with This Genotype

Genotype
MGI:5521529

• Allelic Composition: Nr1h4^tm1.1Mbj/Nr1h4^tm1.1Mbj
• Genetic Background: B6N.B6-Nr1h4^tm1.1Mbj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Nr1h4^tm1.1Mbj/Nr1h4^tm1.1Mbj livers show perisinusoidal/sinusoidal foam cells, lobular inflammation and ballooning degeneration

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:200842 )

♂N • mice exhibit normal respiratory exchange ratio and core body temperature

increased circulating bilirubin level ( J:200842 )

♂ • more than 20-fold

decreased circulating glucose level ( J:200842 )

♂ • in fasting mice at 30 weeks

decreased circulating insulin level ( J:200842 )

♂ • in fasting mice at 30 weeks

increased circulating cholesterol level ( J:200842 )

♂ • total and non-HDL

decreased circulating free fatty acids level ( J:200842 )

♂ • non-esterified

increased circulating alanine transaminase level ( J:200842 )

♂ • more than 4-fold

increased energy expenditure ( J:200842 )

♂ • relative to weight

impaired glucose tolerance ( J:200842 )

♂ • at 30 weeks

increased bile salt level ( J:200842 )

♂ • more than 30-fold

increased liver triglyceride level ( J:200842 )

♂ • at 30 weeks

liver/biliary system

abnormal liver sinusoid morphology ( J:200842 )

♂ • perisinusoidal/sinusoidal foam cells

enlarged gallbladder ( J:200842 )

♂ • 5-fold increase in weight for non-emptied gall bladder

increased liver weight ( J:200842 )

♂ • at 30 weeks

increased liver triglyceride level ( J:200842 )

♂ • at 30 weeks

abnormal liver perisinusoidal space morphology ( J:200842 )

♂ • perisinusoidal/sinusoidal foam cells

hepatic steatosis ( J:200842 )

♂ • non-alcoholic steatohepatitis

liver degeneration ( J:200842 )

♂ • ballooning

abnormal liver physiology ( J:200842 )

♂

liver inflammation ( J:200842 )

♂ • lobular, non-alcoholic steatohepatitis

jaundice ( J:200842 )

♂ • yellow paws and plasma at 39 weeks

adipose tissue

decreased total body fat amount ( J:200842 )

♂ • at 30 weeks

decreased white fat cell size ( J:200842 )

♂

decreased epididymal fat pad weight ( J:200842 )

♂

decreased retroperitoneal fat pad weight ( J:200842 )

♂

decreased interscapular fat pad weight ( J:200842 )

♂ • with reduced density

growth/size/body

growth/size/body region phenotype ( J:200842 )

♂N • mice exhibit normal lean mass

enlarged gallbladder ( J:200842 )

♂ • 5-fold increase in weight for non-emptied gall bladder

decreased body weight ( J:200842 )

♂ • at 21 and 39 weeks

increased liver weight ( J:200842 )

♂ • at 30 weeks

increased spleen weight ( J:200842 )

♂

skeleton

decreased bone mineral content ( J:200842 )

♂ • at 30 weeks

decreased bone mineral density ( J:200842 )

♂ • slightly at 9 weeks

♂ • at 30 weeks

behavior/neurological

increased fluid intake ( J:200842 )

♂ • relative to weight at 29 to 31 weeks

increased food intake ( J:200842 )

♂ • increased energy intake relative to weight at 29 to 31 weeks

♂ • however, relative total energy uptake is normal

immune system

increased spleen weight ( J:200842 )

♂

liver inflammation ( J:200842 )

♂ • lobular, non-alcoholic steatohepatitis

endocrine/exocrine glands

enlarged gallbladder ( J:200842 )

♂ • 5-fold increase in weight for non-emptied gall bladder

digestive/alimentary system

increased cecum weight ( J:200842 )

♂

integument

integument phenotype ( J:200842 )

♂N • mice exhibit normal skin morphology

hematopoietic system

increased spleen weight ( J:200842 )

♂

cardiovascular system

abnormal liver sinusoid morphology ( J:200842 )

♂ • perisinusoidal/sinusoidal foam cells