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Phenotypes Associated with This Genotype
Genotype
MGI:5520923
Allelic
Composition
Pla2g2dtm1.1Mhg/Pla2g2dtm1.1Mhg
Genetic
Background
B6NCrSlc.Cg-Pla2g2dtm1.1Mhg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g2dtm1.1Mhg mutation (0 available); any Pla2g2d mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal dendritic cell, T cell, B cell and macrophage populations in spleen, inguinal and mesenteric lymph nodes, Peyer's patch and thymus
• of activated dendritic cells in hapten-treated mice
• increased in hapten-treated mice
• slight increase in the proportion of splenic CD4+ T cells (J:201008)
• lungs of SARS-CoV-infected mice exhibit a higher frequency and number of virus-specific CD4 T cells (J:229035)
• lungs of SARS-CoV-infected mice exhibit a higher frequency and number of virus-specific CD8 T cells
• SARS-CoV-infected mice show augmented CD8 T cell cytolytic activity
• CD8 T cell responses are higher in the lungs of influenza A virus-infected mice at 10 days post infection
• hyperactive following LPS treatment
• mice exhibit a higher frequency and number of respiratory dendritic cells (rDCs) that migrate to the mediastinal lymph nodes (MLN) than wild-type mice
• SARS-CoV-infected middle-aged mice show a higher frequency and number of rDCs that migrate from lungs to MLN compared to infected wild-type mice
• influenza A virus-infected mice show a higher frequency and number of rDCs in the MLN at 18 hours post infection
• hapten-treated mice exhibit impaired resolution (determined by ear swelling, increased activated dendritic cells and increased effector T cells) compared with wild-type mice
• however, mice exhibit normal antigen uptake, recruitment and activation of skin dendritic cells migrating into the lymph nodes
• CD8 T cell from SARS-CoV-infected mice produce more IFN-gamma per cell
• from bone marrow-derived dendritic cells in response to suboptimal LPS treatment
• from bone marrow-derived dendritic cells in response to suboptimal LPS treatment
• middle-aged mice show decreased susceptibility to infection with SARS-CoV MA15 , showing increased survival, increased viral clearance mediated by a more robust T cell response, and decreased pathological changes in the lungs
• more than 80% of middle-aged mice infected with SARS-CoV MA15 survive the infection compared to 0% survival in controls
• however, mice infected with the PR8 strain of influenza A virus show similar survival as controls

mortality/aging
• more than 80% of middle-aged mice infected with SARS-CoV MA15 survive the infection compared to 0% survival in controls
• however, mice infected with the PR8 strain of influenza A virus show similar survival as controls

homeostasis/metabolism
• decreased arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid in lymph nodes
• middle-aged, but not young, mice show lower levels of arachidonic acid
• middle-aged mice infected with SARS-CoV exhibit lower levels of free polyunsaturated fatty acids, arachidonic acid, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) in the lungs than controls

hematopoietic system
• mice exhibit a higher frequency and number of respiratory dendritic cells (rDCs) that migrate to the mediastinal lymph nodes (MLN) than wild-type mice
• SARS-CoV-infected middle-aged mice show a higher frequency and number of rDCs that migrate from lungs to MLN compared to infected wild-type mice
• influenza A virus-infected mice show a higher frequency and number of rDCs in the MLN at 18 hours post infection
• of activated dendritic cells in hapten-treated mice
• increased in hapten-treated mice
• slight increase in the proportion of splenic CD4+ T cells (J:201008)
• lungs of SARS-CoV-infected mice exhibit a higher frequency and number of virus-specific CD4 T cells (J:229035)
• lungs of SARS-CoV-infected mice exhibit a higher frequency and number of virus-specific CD8 T cells
• SARS-CoV-infected mice show augmented CD8 T cell cytolytic activity
• CD8 T cell responses are higher in the lungs of influenza A virus-infected mice at 10 days post infection

cellular
• mice exhibit a higher frequency and number of respiratory dendritic cells (rDCs) that migrate to the mediastinal lymph nodes (MLN) than wild-type mice
• SARS-CoV-infected middle-aged mice show a higher frequency and number of rDCs that migrate from lungs to MLN compared to infected wild-type mice
• influenza A virus-infected mice show a higher frequency and number of rDCs in the MLN at 18 hours post infection


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory